Sebastian Oltean Selected Research

Neoplasms (Cancer)

10/2023	Regulation of Epithelial-Mesenchymal Transitions by Alternative Splicing: Potential New Area for Cancer Therapeutics.
1/2023	Detection of genomic mutations in blood and urine free circulating tumour DNA in patients with inoperable and metastatic lung adenocarcinoma harbouring an EGFR mutation in tissue: a UK pilot study.
6/2022	A repositioning screen using an FGFR2 splicing reporter reveals compounds that regulate epithelial-mesenchymal transitions and inhibit growth of prostate cancer xenografts.
12/2021	CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.
5/2019	Targeting Angiogenesis in Prostate Cancer.
1/2019	Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis.
1/2019	Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing.
11/2017	Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype.
10/2017	The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
2/2016	Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.

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Sebastian Oltean Research Topics

Disease

18	Neoplasms (Cancer) 10/2023 - 09/2006
10	Prostatic Neoplasms (Prostate Cancer) 06/2022 - 08/2011
3	Diabetic Nephropathies (Diabetic Nephropathy) 02/2018 - 08/2015
3	Colorectal Neoplasms (Colorectal Cancer) 01/2015 - 12/2009
2	Osteosarcoma (Osteogenic Sarcoma) 01/2020 - 01/2019
2	Disease Progression 01/2019 - 01/2016
2	Chronic Renal Insufficiency 02/2018 - 10/2017
2	Denys-Drash Syndrome 02/2018 - 12/2009
2	Fibrosis (Cirrhosis) 11/2017 - 01/2017
2	Proteinuria 10/2017 - 10/2012
1	Adenocarcinoma of Lung 01/2023
1	Cholangiocarcinoma 01/2020
1	Neoplasm Metastasis (Metastasis) 05/2019
1	Pathologic Neovascularization 01/2019
1	Bone Neoplasms (Bone Cancer) 01/2019
1	Kidney Diseases (Kidney Disease) 02/2018
1	Neuroblastoma 10/2017
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2017
1	Type 2 Diabetes Mellitus (MODY) 08/2015
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/2015
1	Adenoma (Adenomas) 01/2015
1	Carcinoma (Carcinomatosis) 01/2015
1	Colonic Neoplasms (Colon Cancer) 01/2015
1	Renal Insufficiency (Renal Failure) 12/2011
1	Wilms Tumor (Wilm's Tumor) 12/2011
1	Circulating Neoplastic Cells 08/2011
1	Breast Neoplasms (Breast Cancer) 08/2011
1	Retinal Vein Occlusion 12/2009
1	Melanoma (Melanoma, Malignant) 12/2009
1	Diabetic Retinopathy (Retinopathy, Diabetic) 12/2009
1	Pre-Eclampsia (Preeclampsia) 12/2009
1	Macular Degeneration (Age-Related Maculopathy) 12/2009
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2005
1	Phosphoglycerate Kinase 1 Deficiency 02/2003
1	Acute Kidney Injury (Acute Renal Failure) 02/2003
1	Rhabdomyolysis 02/2003

Drug/Important Bio-Agent (IBA)

15	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2019 - 12/2009
10	Protein Isoforms (Isoforms)IBA 02/2018 - 09/2006
5	Transcription Factors (Transcription Factor)IBA 01/2020 - 10/2017
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2009
2	Phosphotransferases (Kinase)IBA 12/2021 - 12/2009
2	Protein Kinases (Protein Kinase)IBA 12/2021 - 02/2016
2	OligonucleotidesIBA 01/2020 - 01/2019
2	MorpholinosIBA 01/2020 - 01/2019
2	AndrogensIBA 01/2019 - 10/2015
2	Serine (L-Serine)FDA Link 02/2016 - 12/2009
2	Arginine (L-Arginine)FDA Link 02/2016 - 12/2009
2	Bevacizumab (Avastin)FDA Link 01/2015 - 01/2015
2	Messenger RNA (mRNA)IBA 09/2010 - 02/2003
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	Narcotic Antagonists (Opioid Antagonists)IBA 06/2022
1	nemadipine-AIBA 06/2022
1	TG 003IBA 12/2021
1	benzothiazoleIBA 12/2021
1	RNA Splice SitesIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 05/2019
1	RadiopharmaceuticalsIBA 05/2019
1	Hormones (Hormone)IBA 01/2019
1	SteroidsIBA 01/2019
1	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 01/2019
1	RNA IsoformsIBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2017
1	Vincristine (Oncovin)FDA LinkGeneric 10/2017
1	YK 4-279IBA 10/2017
1	BRD32048IBA 10/2017
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2017
1	Sialyl Lewis X AntigenIBA 10/2015
1	sialosyl-Tn antigenIBA 10/2015
1	Androgen Receptors (Androgen Receptor)IBA 10/2015
1	AntigensIBA 10/2015
1	EnzymesIBA 10/2015
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2015
1	AntibodiesIBA 01/2015
1	VimentinIBA 08/2011
1	Cadherins (E-Cadherin)IBA 08/2011
1	Peptides (Polypeptides)IBA 09/2010
1	RNA Splicing FactorsIBA 12/2009
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 09/2006
1	HomocysteineIBA 09/2005
1	SulfurIBA 09/2005
1	Amino Acids FDA Link 09/2005

Therapy/Procedure

9	Therapeutics 10/2023 - 12/2009
3	Castration 05/2019 - 08/2011
1	Prostatectomy (Retropubic Prostatectomy) 01/2020
1	Injections 08/2015
1	Drug Therapy (Chemotherapy) 01/2015